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NS 1619

SIGMA/N170 - powder

Synonym: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

CAS Number: 153587-01-0
Empirical Formula (Hill Notation): C15H8F6N2O2
Molecular Weight: 362.23
MDL Number: MFCD00928190
Linear Formula: C15H8F6N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N170-5MG 5 mg
 $208.00
1/EA		 Add To Favorites
45-N170-25MG 25 mg
 $711.00
1/EA		 Add To Favorites

 

color white
form powder
InChI 1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key YLFMCMWKHSDUCT-UHFFFAOYSA-N
Quality Level 200 
SMILES string Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
solubility 0.1 M NaOH: 5.2 mg/mL
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
  DMSO: 5.3 mg/mL
  ethanol: 26.6 mg/mL
  H2O: insoluble
Application: NS 1619 has been used as calcium-activated potassium channels (BK)-activator: to study its vaso-relaxing effects on the thoracic aortic rings from mice, to evaluate its effects on the sarco-/endoplasmic reticulum Ca2+-ATPase (SERCA) activity from skeletal muscles, to determine its effects on the expression of caveolin-1 protein in mice brain tumor microvascular endothelial cells
Biochem/physiol Actions: NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
Biochem/physiol Actions: NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.
Disclaimer: Photosensitive
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352200

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