Naftifine hydrochloride

SIGMA/N1790

Synonym: Naftifine HCL

CAS Number: 65473-14-5
Empirical Formula (Hill Notation): C₂₁H₂₁N · HCl
Molecular Weight: 323.86
MDL Number: MFCD00059047
Linear Formula: C₂₁H₂₁N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N1790-50MG	50 mg	$340.00 1/EA	Add To Favorites
45-N1790-500MG	500 mg	$1220.00 1/EA	Add To Favorites

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This image depicts SKU: N1790-500MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-negative bacteria
	Gram-positive bacteria
	yeast
assay	≥99%
form	powder
InChI	1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
InChI key	OLUNPKFOFGZHRT-YGCVIUNWSA-N
mode of action	cell wall synthesis \| interferes
	enzyme \| inhibits
Quality Level	200
SMILES string	Cl.CN(CC=Cc1ccccc1)Cc2cccc3ccccc23
solubility	ethanol: soluble 50 mg/mL
storage temp.	2-8°C

Application:	Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.
Biochem/physiol Actions:	Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.
Biochem/physiol Actions:	Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Light sensitive.
Packaging:	50, 500 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	nwg
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99%
Storage Temp.	2-8°C
UNSPSC	51102829

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