Neomycin trisulfate salt hydrate

SIGMA/N1876 - powder

Synonym: Framycetin sulfate

CAS Number: 1405-10-3
Empirical Formula (Hill Notation): C₂₃H₄₆N₆O₁₃ · 3H₂SO₄ · xH₂O
Molecular Weight: 908.88 (anhydrous basis)
EC Number: 215-773-1
Linear Formula: C₂₃H₄₆N₆O₁₃ · 3H₂SO₄ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N1876-25G	25 g	$66.90 1/EA	Add To Favorites
45-N1876-100G	100 g	$205.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N1876-100G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
form	powder
InChI	1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;31-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1
InChI key	WHAGUNPVKDUVFV-QGTTWHFQSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O

Application:	Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo), and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins..
Biochem/physiol Actions:	Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons. Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
Packaging:	25, 100 g in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P342 + P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51101500

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