Neostigmine bromide
SIGMA/N2001 - ≥98% (HPLC and titration), powder
Synonym: 3-
CAS Number: 114-80-7
Empirical Formula (Hill Notation): C12H19BrN2O2
Molecular Weight: 303.20
EC Number: 204-054-8
MDL Number: MFCD00011795
Linear Formula: C12H19BrN2O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N2001-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N2001-5G
| assay | ≥98% (HPLC and titration) |
| color | white |
| form | powder |
| InChI | 1S/C12H19N2O2.BrH/c1-13(2 |
| InChI key | LULNWZDBKTWDGK-UHFFFAOYSA |
| mp | 175-177 °C (lit.) |
| Quality Level | 100  |
| SMILES string | [Br-].CN(C)C(=O)Oc1cccc(c |
| solubility | ethanol: soluble |
| H2O: 1 g/mL |
| Application: | Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor: • to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri. • to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS). • to study its effects on depolarization of bag cell neurons. |
| Biochem/physiol Actions: | Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers. |
| Biochem/physiol Actions: | Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier. |
| Biochem/physiol Actions: | Reversible inhibitor of acetylcholinesterase; does not cross the blood-brain barrier. |
| Features and Benefits: | This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 1, 5, 10 g in poly bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 - H315 - H317 - H319 - H334 - H335 |
| Precautionary statements | P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38-42/43 |
| Safety Statements | 22-26-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC and titration) |
| mp | 175-177 °C (lit.) |
| UNSPSC | 12352200 |