Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse
SIGMA/N216 - clone C2C12
MDL Number: MFCD01865491
Product Type: Chemical
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| antibody product type | primary antibodies |
| biological source | mouse |
| clone | C2C12, monoclonal |
| conjugate | unconjugated |
| form | liquid |
| isotype | IgM |
| mol wt | antigen 120 kDa (mature exchanger) |
| antigen 160 kDa (non-reduced) | |
| antigen 70 kDa (proteolytic fragment) | |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | human, rat, canine, rabbit, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (frozen sections): 1:200 |
| immunoprecipitation (IP): suitable | |
| western blot: 1:1,000 | |
| UniProt accession no. | P32418  |
| Biochem/physiol Actions: | Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+. |
| Biochem/physiol Actions: | The antibody reacts specifically with Na+/Ca2+ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters. |
| Immunogen: | dog cardiac Na+/Ca2+ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane. |
| Physical form: | Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |