NH125
SIGMA/N2162 - ≥98% (HPLC), solid
Synonym: 1-
CAS Number: 278603-08-0
Empirical Formula (Hill Notation): C27H45IN2
Molecular Weight: 524.56
MDL Number: MFCD07370143
Linear Formula: C27H45IN2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C27H45N2.HI/c1-3-4-5-6 |
| InChI key | RVWOHCBHAGBLLT-UHFFFAOYSA |
| mp | 88.2-94.9 °C |
| Quality Level | 100  |
| SMILES string | [I-].CCCCCCCCCCCCCCCC[n+] |
| solubility | DMSO: >20 mg/mL |
| storage temp. | −20°C |
| Analysis Note: | IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM). |
| Biochem/physiol Actions: | NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase. |
| Biochem/physiol Actions: | NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K). |
| Packaging: | 5, 25 mg in glass bottle |
| Packaging: | Packaged under nitrogen. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 88.2-94.9 °C |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |