Monoclonal Anti-Nitric Oxide Synthase, Universal antibody produced in mouse
SIGMA/N218 - clone NOS-3F7-B11-B5, ascites fluid
Synonym: Anti-IHPS1; Anti-N-NOS; Anti-NC-NOS; Anti-NOS; Anti-bNOS; Anti-nNOS
MDL Number: MFCD01324876
Product Type: Chemical
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| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | NOS-3F7-B11-B5, monoclonal |
| conjugate | unconjugated |
| isotype | IgM |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse, bovine, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (frozen sections): 1:100 |
| western blot: 1:50-1:500 | |
| UniProt accession no. | P29476  |
| Biochem/physiol Actions: | Neuronal nitric acid synthase (Nos1) in involved in the production of nitric oxide. Mutations in the gene encoding it increases the susceptibility to behavioral dysfunction after an exposure to alcohol in mice. |
| Biochem/physiol Actions: | The antibody reacts with iNOS, eNOS and nNOS from rat and bovine, and with iNOS in induced RAW 264.7 mouse macrophages. In immunoblotting, the antibody detects a band at 130 kDa representing iNOS in samples first induced with IFN (interferon) and LPS (lipopolysaccharides). It also detects a band at 155 kDa in tissues expressing nNOS and a band at 140 kDa in tissues expressing eNOS. The antibody may be used to localize and detect the three isoforms of nitric oxide synthase (NOS): neuronal or brain (nNOS or bNOS), endothelial (eNOS) and inducible (iNOS). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | bovine cerebellum NOS. |
| Physical form: | Ascites fluid containing ≤0.1% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |