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NS5806

SIGMA/N2540 - ≥98% (HPLC)

Synonym: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

CAS Number: 426834-69-7
Empirical Formula (Hill Notation): C16H8Br2F6N6O
Molecular Weight: 574.07
MDL Number: MFCD18432708
Linear Formula: C16H8Br2F6N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N2540-5MG 5 mg
 $161.00
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45-N2540-25MG 25 mg
 $620.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to faint yellow
form powder
InChI 1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
InChI key UZWJWROOLOOCPQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c3nnn[nH]3)cc(c1)C(F)(F)F
solubility DMSO: >30 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.
Biochem/physiol Actions: NS5806 is an activator or transient outward potassium current (Ito).
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301 - H413
Precautionary statements P273 - P301 + P310 + P330
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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