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Nucleozin

SIGMA/N2790 - ≥98% (HPLC), powder

Synonym: Nucleozin; 1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine; [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone

CAS Number: 341001-38-5
Empirical Formula (Hill Notation): C21H19ClN4O4
Molecular Weight: 426.85
MDL Number: MFCD01426660
Linear Formula: C21H19ClN4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N2790-5MG 5 mg
 $114.00
1/EA		 Add To Favorites
45-N2790-25MG 25 mg
 $431.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChI key OWXBJAPOSQSWAO-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O
solubility DMSO: >15 mg/mL
storage temp. 2-8°C
Application: Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.
Biochem/physiol Actions: Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.
Biochem/physiol Actions: Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.
Biochem/physiol Actions: Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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