PYR-41

SIGMA/N2915 - ≥98% (HPLC), powder

Synonym: 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester

CAS Number: 418805-02-4
Empirical Formula (Hill Notation): C₁₇H₁₃N₃O₇
Molecular Weight: 371.30
Linear Formula: C₁₇H₁₃N₃O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N2915-5MG	5 mg	$111.00 1/EA		Add To Favorites
45-N2915-25MG	25 mg	$336.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	red to brown
form	powder
InChI	1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI key	ARGIPZKQJGFSGQ-UKTHLTGXSA-N
Quality Level	100
SMILES string	CCOC(=O)c1ccc(cc1)N2NC(=O)C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Application:	PYR-41 has been used as E1 inhibitor: • to determine the cellular degradation pathways on adeno-associated viruses (AAV) transduction • to assess its selectivity and potency by matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) E2/E3 assay • to treat fully differentiated C2C12 myotubes in high glucose medium for determining its effect on protein ubiquitination and cell viability • in the pretreatment of human brain microvascular endothelial cells (hBMECs) for the inhibition studies before infection with bacteria
Biochem/physiol Actions:	PYR-41 inhibits E1 ubiquitin ligases like mouse double minute 2 homolog (MDM2), Itchy (ITCH) and HOIL-1L interacting protein (HOIP). It has anticancer potential.
Biochem/physiol Actions:	PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.
Biochem/physiol Actions:	PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1).
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H317
Precautionary statements	P280 - P301 + P312 + P330 - P302 + P352
Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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