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Necrostatin-7

SIGMA/N3040 - ≥98% (HPLC), powder

Synonym: 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone; Nec-7

CAS Number: 351062-08-3
Empirical Formula (Hill Notation): C16H10FN5OS2
Molecular Weight: 371.41
MDL Number: MFCD02334728
Linear Formula: C16H10FN5OS2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N3040-5MG 5 mg
 $96.50
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assay ≥98% (HPLC)
color yellow to tan
form powder
InChI 1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
InChI key SMJGLNVGTJLIRV-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
solubility DMSO: >10 mg/mL (with warming)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.
Biochem/physiol Actions: Necrostatin-7 is a potent inhibitor of necroptosis.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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