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NKH 477

SIGMA/N3290 - ≥98% (HPLC), powder

Synonym: 6-[3-(dimethylamino)propionyl]-forskolin; Colforsin dapropate hydrochloride; N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride

CAS Number: 138605-00-2
Empirical Formula (Hill Notation): C27H43NO8·HCl
Molecular Weight: 546.09
MDL Number: MFCD00236421
Linear Formula: C27H43NO8·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N3290-5MG 5 mg
 $170.00
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45-N3290-25MG 25 mg
 $640.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts N3290-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChI key VIRRLEDAYYYTOD-YHEOSNBFSA-N
Quality Level 100 
SMILES string Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C
solubility H2O: 3 mg/mL, clear to slightly hazy (warmed)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: NKH 477 is a potent, orally active adenylyl cyclase activator.
Biochem/physiol Actions: NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Preparation Note: A clear to slightly hazy solution is possible.
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H300
Precautionary statements P264 - P301 + P310
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 2811 6.1 / PGII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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