Synonym: (RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide; (±)-Nifurtimox; 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide; BAY 2502; Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide
CAS Number: 23256-30-6
Empirical Formula (Hill Notation): C10H13N3O5S
Molecular Weight: 287.29
EC Number: 245-531-0
MDL Number: MFCD00869254
Linear Formula: C10H13N3O5S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow to orange |
| form |
powder |
| InChI |
1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+ |
| InChI key |
ARFHIAQFJWUCFH-IZZDOVSWSA-N |
| originator |
Bayer |
| Quality Level |
100  |
| SMILES string |
CC1CS(=O)(=O)CCN1N=Cc2ccc(o2)[N+]([O-])=O |
| solubility |
DMSO: ≥13 mg/mL |
| storage temp. |
room temp |
| Application: |
Nifurtimox has been used in drug treatment in culture media. |
| Biochem/physiol Actions: |
Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. |
| Biochem/physiol Actions: |
Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen. |
| Features and Benefits: |
This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions. It is used to treat Chagas disease and African trypanosomiasis. Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
