Niclosamide

SIGMA/N3510

Synonym: 2′,5-Dichloro-4′-nitrosalicylanilide

CAS Number: 50-65-7
Empirical Formula (Hill Notation): C₁₃H₈Cl₂N₂O₄
Molecular Weight: 327.12
EC Number: 200-056-8
MDL Number: MFCD00057597
Linear Formula: C₁₃H₈Cl₂N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N3510-50G	50 g	$145.00 1/EA		Add To Favorites
45-N3510-250G	250 g	$629.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	parasites
form	powder
InChI	1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key	RJMUSRYZPJIFPJ-UHFFFAOYSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O

Application:	Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.
Biochem/physiol Actions:	Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.
Other Notes:	50g,250g
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51102829

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