Nicorandil
SIGMA/N3539 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 65141-46-0
Empirical Formula (Hill Notation): C8H9N3O4
Molecular Weight: 211.17
EC Number: 265-514-1
MDL Number: MFCD00186520
Linear Formula: C8H9N3O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C8H9N3O4/c12-8(7-2-1-3 |
| InChI key | LBHIOVVIQHSOQN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [O-][N+](=O)OCCNC(=O)c1cc |
| solubility | DMSO: >10 mg/mL |
| storage temp. | room temp |
| Application: | Nicorandil has been used as an activator of potassium (K+) channel and inhibitor of voltage-gated calcium channel to study its effects on action potentials in long QT syndrome 2 (LQTS2) human induced pluripotent stem cell (hiPSCs)-derived cardiomyocytes. |
| Biochem/physiol Actions: | Nicorandil exhibits cardio-protective effects. |
| Biochem/physiol Actions: | Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. |
| Biochem/physiol Actions: | Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 50, 250 mg in glass bottle |
| Symbol |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H242 - H302 |
| Precautionary statements | P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |