Neuromedin B

SIGMA/N3762 - ≥90% (HPLC)

CAS Number: 87096-84-2
Empirical Formula (Hill Notation): C₅₂H₇₃N₁₅O₁₂S
Molecular Weight: 1132.29
MDL Number: MFCD00167607
Linear Formula: C₅₂H₇₃N₁₅O₁₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N3762-1MG	1 mg	$290.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
InChI	1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)
InChI key	YPFNACALNKVZNK-UHFFFAOYSA-N
Quality Level	100
SMILES string	CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O
storage temp.	−20°C

Amino Acid Sequence:	Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Application:	Neuromedin B (NMB) has been used as a bombesin (BN)-like peptide: • for injection in mice to understand energy expenditure and oxygen consumption and CO2 production • to study its effects on the thyrotropin (TSH) and prolactin (PRL) release in vitro • to analyze its effects on angiogenesis through the activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in endothelial cells
Biochem/physiol Actions:	Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.
Features and Benefits:	This compound is featured on the Bombesin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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