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NBI 27914

SIGMA/N3911 - ≥98% (HPLC)

Synonym: 5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine

CAS Number: 184241-44-9
Empirical Formula (Hill Notation): C18H20Cl4N4
Molecular Weight: 434.19
MDL Number: MFCD05662281
Linear Formula: C18H20Cl4N4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N3911-10MG 10 mg
 $175.00
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assay ≥98% (HPLC)
color white
form solid
InChI 1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChI key KNADXBVKFAUMCR-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
solubility DMSO: >20 mg/mL at 60 °C
  H2O: insoluble
storage temp. 2-8°C
Application: NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
• to study its effects on steroidogenic gene expression in GD15 mouse testis
• to study its effects on amyloid β production
• to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Biochem/physiol Actions: NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
Packaging: 10, 50 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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