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S-Nitrosoglutathione

SIGMA/N4148 - ≥97%

Synonym: GSNO; SNOG

CAS Number: 57564-91-7
Empirical Formula (Hill Notation): C10H16N4O7S
Molecular Weight: 336.32
MDL Number: MFCD00214341
Linear Formula: C10H16N4O7S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N4148-25MG 25 mg
 $424.00
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45-N4148-50MG 50 mg
 $480.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N4148-50MG

 

assay ≥97%
form powder
InChI 1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
InChI key HYHSBSXUHZOYLX-WDSKDSINSA-N
Quality Level 200 
SMILES string N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
solubility water: soluble 19.60-20.40 mg/mL
storage temp. −20°C
Application: S-Nitrosoglutathione (GSNO) has been used:
• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.
Biochem/physiol Actions: S-Nitrosoglutathione (GSNO) inhibits the activity of sarcoplasmic reticulum-bound creatine kinase in rabbit skeletal muscle and eventually reduces ATP driven Ca2+ uptake in sarcoplasmic reticulum vesicles. GSNO in airway cells relaxes airway smooth muscle and enhances airway ciliary motility. It also blocks airway epithelial amiloride-sensitive sodium transport while stimulating calcium-dependent epithelial chloride transport and induces neutrophilic apoptosis. In addition, it also has antimicrobial activity. GSNO concentration is low in cystic fibrosis (CF) airway. It is an NO donor, acts as a smooth muscle relaxant, vasodilator and inhibits platelet activation in vivo.
General description: S-Nitrosoglutathione (GSNO) is an endogenous nitrogen oxide and is highly distributed in extracellular fluids of the lung and brain.
Packaging: 25 mg in poly bottle
Packaging: 50 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥97%
Storage Temp. −20°C
UNSPSC 12352200

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