Neuron-specific enolase from human brain
SIGMA/N4773 - ≥95% (SDS-PAGE), buffered aqueous solution
Synonym: 2-Phospho-D-glycerate hydro-lyase; Enolase, Neuron-specific from human brain; NSE; Thermolabile antigen A
MDL Number: MFCD00081785
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human brain |
| form | buffered aqueous solution |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥10 units/mg protein |
| storage temp. | −20°C |
| UniProt accession no. | P09104  |
| Application: | Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features. |
| Biochem/physiol Actions: | Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE. |
| Biochem/physiol Actions: | Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner. |
| General description: | Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue. |
| Other Notes: | One unit causes the formation of 1.0 μmole of phospho(enol)pyruvate per minute at pH 6.8 at 25 °C |
| Physical form: | Solution in 100 mM Tris-HCl, 5 mM MgSO4, 250 mM KCl, pH 5.0-5.2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| activity | specific activity: ≥10 units/mg protein |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 4.2.1.11 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |