Synonym: 3-(Aminocarbonyl)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-Amino-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl]methoxy}(Hydroxy)phosphoryl]oxy} (Hydroxy)phosphoryl]ox; NGD
CAS Number: 5624-35-1
Empirical Formula (Hill Notation): C21H28N7O15P2
Molecular Weight: 680.43
MDL Number: MFCD00079505
Linear Formula: C21H28N7O15P2
Product Type: Chemical
| assay |
≥-96% |
| biological source |
yeast |
| form |
powder |
| InChI |
1S/C21H28N7O15P2/c22-16(33)8-2-1-3-27(4-8)19-14(31)12(29)9(41-19)5-39-44(35,36)43-45(37,38)40-6-10-13(30)15(32)20(42-10)28-7-24-11-17(28)25-21(23)26-18(11)34/h1-4,7,9-10,12-15,19-20,29-32H,5-6H2,(H2,22,33)(H,35,36)(H,37,38)(H3,23,25,26,34) |
| InChI key |
WWXCUPZEUROLRY-UHFFFAOYSA-N |
| Quality Level |
200  |
| SMILES string |
NC(=O)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5C(=O)N=C(N)Nc45)C(O)C2O |
| solubility |
H2O: soluble-50 mg/mL, clear, almost colorless to slightly yellow |
| storage temp. |
−20°C |
| Application: |
Nicotinamide guanine dinucleotide (NGD+) may be used as a preferred substrate of specific snake Trimeresurus stejnegeri venom phospodiesterase and a substrate to study the specificity and kinetics of ADP-ribosyl cyclase(s). |
| Application: |
Nicotinamide guanine dinucleotide sodium salt has been used as a substrate for measuring the cyclase activity of the enzyme cluster of differentiation 38 (CD38). It has also been used as a substrate to fluorometrically determine the activity of CD38/ADP-ribose (ADPR). |
| Biochem/physiol Actions: |
Nicotinamide guanine dinucleotide sodium salt is used to determine the activity of proteins that generate cyclic-ADP-ribose (cADPR) in the ADP-ribosyl cyclase family. |
| Other Notes: |
Analog of β-NAD |
| Packaging: |
25 mg in poly bottle |
| Packaging: |
5 mg in glass bottle |
| Purity |
≥-96% |
| Storage Temp. |
−20°C |
| UNSPSC |
41106305 |
GHS07