Nodularin

SIGMA/N5148 - cyanotoxin

Synonym: 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

CAS Number: 118399-22-7
Empirical Formula (Hill Notation): C₄₁H₆₀N₈O₁₀
Molecular Weight: 824.96
MDL Number: MFCD16659855
Linear Formula: C₄₁H₆₀N₈O₁₀
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N5148-250UG	250 µg	$703.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥94% (TLC)
biological source	microbial
form	film or powder
InChI	1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1
InChI key	IXBQSRWSVIBXNC-HSKGSTCASA-N
Quality Level	200
SMILES string	CO[C@@H](Cc1ccccc1)[C@@H](C)C=C(C)C=C[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)C(=CC)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O
solubility	methanol: 2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.)
storage temp.	2-8°C

Application:	Nodularin has been used to induce oxidative stress and analyse its dynamics in flounder liver. It has also been used as standard for identification and quantification by high performance liquid chromatography (HPLC).
Biochem/physiol Actions:	Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.
General description:	Nodularin is a cyclic pentapeptide toxin produced by the cyanobacteria Nodularia spumigena.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H315 - H317 - H319 - H335
Precautionary statements	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	T+
Risk Statements	26/27/28-36/37/38-43
Safety Statements	26-36/37/39-45
RIDADR	UN 2811PIH 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥94% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352202

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