3-Nitropropionic acid
SIGMA/N5636 - ≥97%
CAS Number: 504-88-1
Empirical Formula (Hill Notation): C3H5NO4
Molecular Weight: 119.08
EC Number: 208-003-0
MDL Number: MFCD00007406
Linear Formula: O2N(CH2)2CO2H
Product Type: Chemical
| assay | ≥97% |
| biological source | synthetic |
| color | white to light yellow |
| form | powder or crystals |
| InChI | 1S/C3H5NO4/c5-3(6)1-2-4(7 |
| InChI key | WBLZUCOIBUDNBV-UHFFFAOYSA |
| mp | 68-70 °C (lit.) |
| Quality Level | 100  |
| SMILES string | OC(CC[N+]([O-])=O)=O |
| solubility | alcohol: may be light yellow 100 mg/mL |
| storage temp. | 2-8°C |
| Application: | 3-Nitropropionic acid has been used: • to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts • to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system • as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines |
| Biochem/physiol Actions: | Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II. |
| Biochem/physiol Actions: | Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease. |
| Packaging: | 10 g in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P330 + P331 + P310 |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% |
| mp | 68-70 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |