Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat
SIGMA/N5788 - affinity isolated antibody, lyophilized powder
Synonym: Anti-LNGFR; Anti-Ngfr; Anti-Tnfrsf16; Anti-p75
MDL Number: MFCD00282384
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 5-15 μg/mL |
| western blot: 2 μg/mL | |
| UniProt accession no. | Q9Z0W1  |
| Application: | Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 2 μg/ml. For immunohistochemistry a working concentration of 5-15 μg/ml is recommended. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes mouse NGF R. Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. |
| General description: | Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes mouse NGF R. |
| Immunogen: | purified, NSO cell-derived recombinant mouse nerve growth factor receptor extracellular domain. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |