β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

SIGMA/N6005 - ≥94% (HPLC)

Synonym: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH

CAS Number: 606-68-8 (anhydrous)
Empirical Formula (Hill Notation): C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
Molecular Weight: 709.40 (anhydrous basis)
MDL Number: MFCD03791273
Linear Formula: C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N6005-1G	1 g	$206.00 1/EA	Add To Favorites
45-N6005-5G	5 g	$862.00 1/EA	Add To Favorites
45-N6005-25G	25 g	$2920.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N6005-25G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥94% (HPLC)
	≥94% (spectrophotometric assay)
biological source	yeast
form	powder
InChI	1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1
InChI key	FWBNCIFELNNJCX-UHOVGGJYSA-L
Quality Level	200
shipped in	wet ice
SMILES string	O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
solubility	10 mM NaOH: soluble-100 mg/mL, clear to slightly hazy, slightly yellow to deep greenish-yellow
storage temp.	−20°C

Application:	β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
Application:	As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Biochem/physiol Actions:	NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD⁺/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease. As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Packaging:	1, 5, 25 g in poly bottle
Packaging:	Packaged by solid weight.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥94% (HPLC); ≥94% (spectrophotometric assay)
Storage Temp.	−20°C
UNSPSC	41106305

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