Norharmane

SIGMA/N6252 - crystalline

Synonym: β-Carboline; 9H-Pyrido[3,4-b]indole

CAS Number: 244-63-3
Empirical Formula (Hill Notation): C₁₁H₈N₂
Molecular Weight: 168.19
EC Number: 205-959-0
MDL Number: MFCD00004956
Linear Formula: C₁₁H₈N₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N6252-100MG	100 mg	$51.90 1/EA		Add To Favorites
45-N6252-500MG	500 mg	$156.00 1/EA		Add To Favorites
45-N6252-1G	1 g	$265.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	light yellow
form	crystalline
InChI	1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
InChI key	AIFRHYZBTHREPW-UHFFFAOYSA-N
Quality Level	200
SMILES string	c1ccc2c(c1)[nH]c3cnccc23
storage temp.	2-8°C

Application:	Norharmane has been used: • as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons • as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates • as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)
Biochem/physiol Actions:	Inhibitor of indoleamine 2,3-dioxygenase (IDO).
Biochem/physiol Actions:	Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
General description:	Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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