Nutlin-3
SIGMA/N6287 - ≥98% (HPLC), powder
Synonym: (±)
CAS Number: 548472-68-0
Empirical Formula (Hill Notation): C30H30Cl2N4O4
Molecular Weight: 581.49
MDL Number: MFCD07784509
Linear Formula: C30H30Cl2N4O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C30H30Cl2N4O4/c1-18(2) |
| InChI key | BDUHCSBCVGXTJM-IZLXSDGUSA |
| ligand | nutlin-3 |
| originator | Roche |
| Quality Level | 100  |
| reaction suitability | reagent type: ligand |
| shipped in | wet ice |
| SMILES string | O=C(N1CC(NCC1)=O)N2C(C3=C |
| solubility | DMSO: 20 mg/mL |
| H2O: insoluble | |
| storage temp. | −20°C |
| Analysis Note: | relative stereochemistry |
| Application: | Nutlin-3 has been used: • as a drug to stimulate p53 functions in gene transfer experiment • to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae • as a p53 activator in cyclotherapy studies • as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage |
| Biochem/physiol Actions: | Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer. |
| Biochem/physiol Actions: | Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Legal Information: | Sold under license from Hoffman-La Roche, Inc. US patent 6,734,302. |
| Other Notes: | Relative stereochemistry; racemic mixture of (4R, 5S) and (4S, 5R) enantiomers. |
| Packaging: | 1, 5 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |