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β-Nicotinamide adenine dinucleotide, reduced disodium salt

SIGMA/N6660 - ~98%, pkg of 0.2 mg (per vial)

Synonym: β-DPNH; β-NADH; Coenzyme I reduced disodium salt; Diphosphopyridine nucleotide reduced disodium salt

CAS Number: 606-68-8
Empirical Formula (Hill Notation): C21H27N7Na2O14P2
Molecular Weight: 709.40
EC Number: 210-123-3
MDL Number: MFCD00036200
Linear Formula: C21H27N7Na2O14P2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N6660-15VL 15 vials
 $903.00
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assay ~98%
form powder
InChI 1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11+,13-,14+,15-,16+,20-,21+;;/m0../s1
InChI key QRGNQKGQENGQSE-QUWMEQBESA-L
packaging pkg of 0.2 mg (per vial)
Quality Level 200 
SMILES string [Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
Application: β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
Application: β-Nicotinamide adenine dinucleotide, reduced disodium salt has been used:
• for the standard curve generation in neurotoxity assay of cortical neurons
• in triosephosphate isomerase assay in jurkat JE6-1 cells
• in lactate dehydrogenase assay
Biochem/physiol Actions: Electron donor
General description: β-Nicotinamide adenine dinucleotide (β-NAD) regulates energy metabolism and immunity. It is a cofactor for mitochondrial deacetylase sirtuin-3 enzyme and modulates inflammasome assembly. β-NAD supresses interleukin-1β levels in monocytic cells in inflammatory syndromes. β-NAD released by neurosecretory cells is a potential neurotransmitter. β-NAD is a vascular mediator in lung endothelial cells and may play a protective role against cytokine mediated inflammation.
Other Notes: Packaged based on NADH content as determined by UV-Vis.
Other Notes: This is the common form of NADH; do not confuse with α-NADH.
Preparation Note: Solutions should be prepared fresh and used promptly.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ~98%
UNSPSC 41106305

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