3-Nitro-L-tyrosine

SIGMA/N7389 - crystalline

CAS Number: 621-44-3
Empirical Formula (Hill Notation): C₉H₁₀N₂O₅
Molecular Weight: 226.19
EC Number: 210-688-6
MDL Number: MFCD00007123
Linear Formula: O₂NC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N7389-5G	5 g	$139.00 1/EA		Add To Favorites
45-N7389-10G	10 g	$261.00 1/EA		Add To Favorites
45-N7389-25G	25 g	$549.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

form	crystalline
InChI	1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1
InChI key	FBTSQILOGYXGMD-LURJTMIESA-N
mp	233-235 °C (dec.) (lit.)
Quality Level	200
SMILES string	N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O

Application:	3-Nitro-L-tyrosine has been used in: • western blot analysis to quantify the nitrotyrosine levels in mice tissue protein • Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization • immunocytochemistry
Biochem/physiol Actions:	3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.
Packaging:	5, 10, 25 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	233-235 °C (dec.) (lit.)
UNSPSC	12352200

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