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NSC 663284

SIGMA/N7537 - ≥98% (HPLC), solid

Synonym: 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

CAS Number: 383907-43-5
Empirical Formula (Hill Notation): C15H16ClN3O3
Molecular Weight: 321.76
MDL Number: MFCD08276924
Linear Formula: C15H16ClN3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N7537-5MG 5 mg
 $261.00
1/EA		 Add To Favorites
45-N7537-25MG 25 mg
 $1030.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color red
form solid
InChI 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI key BMKPVDQDJQWBPD-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
solubility DMSO: ≥10 mg/mL
  H2O: insoluble
storage condition protect from light
storage temp. 2-8°C
Application: NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
Biochem/physiol Actions: NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Biochem/physiol Actions: Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) 470.1 °F
Flash Point(C) 243.4 °C
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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