Naloxone hydrochloride dihydrate
SIGMA/N7758 - ≥98% (TLC and titration), powder
CAS Number: 51481-60-8
Empirical Formula (Hill Notation): C19H21NO4 · HCl · 2H2O
Molecular Weight: 399.87
MDL Number: MFCD00150901
Linear Formula: C19H21NO4 · HCl · 2H2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N7758-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N7758-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N7758-5G
| assay | ≥98% (TLC and titration) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C19H21NO4.ClH.2H2O/c1- |
| InChI key | TXMZWEASFRBVKY-IOQDSZRYSA |
| optical activity | [α]25/D −178.6°, c = 2.5 in H2O(lit.) |
| Quality Level | 200  |
| SMILES string | O.O.Cl.Oc1ccc2C[C@H]3N(CC |
| solubility | ethanol: 3.3 mg/mL |
| H2O: 50 mg/mL | |
| storage temp. | 2-8°C |
| Application: | Naloxone hydrochloride dihydrate has been used in: • isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats • as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear • as a reference neutral antagonist to define the maximum effect (Emax) of the system |
| Biochem/physiol Actions: | Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema. |
| Disclaimer: | Light sensitive. |
| Features and Benefits: | This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 1, 5 g in poly bottle |
| Packaging: | 250 mg in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC and titration) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |