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4-Nitrophenyl 4-guanidinobenzoate hydrochloride

SIGMA/N8010 - protease inhibitor and substrate

Synonym: 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride; NPGB; pNPGB

CAS Number: 19135-17-2
Empirical Formula (Hill Notation): C14H12N4O4 · HCl
Molecular Weight: 336.73
EC Number: 242-831-3
MDL Number: MFCD00037010
Linear Formula: C14H12N4O4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N8010-500MG 500 mg
 $314.00
1/EA		 Add To Favorites
45-N8010-1G 1 g
 $559.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N8010-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N8010-500MG

 

assay ≥95.0% (TLC)
form powder
InChI 1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H
InChI key PKSBDZOBYIKNGY-UHFFFAOYSA-N
Quality Level 200 
SMILES string Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O
solubility formic acid: soluble 49.00-51.00 mg/mL
storage temp. −20°C
Application: 4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
• as a substrate for trypsin for active site titration experiments
• for pre-treating of mosquito eggs in the interplasmid transposition assay
• as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
Biochem/physiol Actions: 4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
General description: 4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
Packaging: 1 g in glass bottle
Packaging: 500 mg in glass bottle
Symbol GHS05  GHS05
Signal word Danger
Hazard statements H318
Precautionary statements P280 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95.0% (TLC)
Storage Temp. −20°C
UNSPSC 12352204

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