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Nikkomycin Z from Streptomyces tendae

SIGMA/N8028 - ≥90% (HPLC)

Synonym: Neopolyoxin C; Nikkomycin Z

CAS Number: 59456-70-1
Empirical Formula (Hill Notation): C20H25N5O10
Molecular Weight: 495.44
MDL Number: MFCD00869648
Linear Formula: C20H25N5O10
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N8028-5MG 5 mg
 $582.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N8028-5MG

 

antibiotic activity spectrum fungi
assay ≥90% (HPLC)
form powder
InChI 1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12+,13-,14-,15+,16+,18+/m0/s1
InChI key WWJFFVUVFNBJTN-JKEIIPFCSA-N
mode of action cell wall synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string C[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3
solubility H2O: soluble 5 mg/mL
storage temp. 2-8°C
Application: Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure.
Biochem/physiol Actions: Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
General description: Chemical structure: peptidyl nucleoside
Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Packaging: 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥90% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51102829

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