N-Nitroso-N-ethylurea

SIGMA/N8509 - Bulk package

Synonym: ENU; N-Ethyl-N-nitrosourea

CAS Number: 759-73-9
Empirical Formula (Hill Notation): C₃H₇N₃O₂
Molecular Weight: 117.11
EC Number: 212-072-2
MDL Number: MFCD00053635
Linear Formula: C₃H₇N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N8509-5G	5 g	$152.00 1/EA	Add To Favorites
45-N8509-25G	25 g	$462.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

contains	aqueous acetic acid as stabilizer
form	powder
InChI	1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
InChI key	FUSGACRLAFQQRL-UHFFFAOYSA-N
Quality Level	100
SMILES string	CCN(N=O)C(N)=O
storage temp.	−20°C

Application:	Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.: This study identifies genetic factors affecting blood pressure and heart rate using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis. The research utilizes automated meiotic mapping to reveal the genetic underpinnings of these cardiovascular traits, providing insights that could inform therapeutic targets (Teixeira et al., 2024 ). Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea.: This study examines the effects of ENU on T lymphocyte clonality and trafficking in mice. The findings provide insights into the mutagenic and immunological impacts of ENU, contributing to our understanding of chemical-induced mutations (Judice et al., 2023 ). Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.: This proof-of-concept study integrates duplex sequencing technology to test genetic toxicity in rats exposed to ENU. The results demonstrate the feasibility and effectiveness of this approach in detecting mutagenic effects, highlighting its potential for genetic toxicity assessment (Smith-Roe et al., 2023 ).
Biochem/physiol Actions:	DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
Packaging:	5, 25 g in glass bottle
Packaging:	Weight on dry basis.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H312 + H332 - H350 - H360
Precautionary statements	P201 - P202 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Codes	T
Risk Statements	45-46-61-20/21/22
Safety Statements	53-22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352102

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