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Necrostatin-1

SIGMA/N9037 - ≥98% (HPLC)

Synonym: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thio-Hydantoin; MTH-DL-Tryptophan

CAS Number: 4311-88-0
Empirical Formula (Hill Notation): C13H13N3OS
Molecular Weight: 259.33
MDL Number: MFCD00056916
Linear Formula: C13H13N3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N9037-10MG 10 mg
 $217.00
1/EA		 Add To Favorites
45-N9037-25MG 25 mg
 $457.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChI key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
solubility DMSO: >10 mg/mL
storage temp. −20°C
Application: Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro. It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.
Biochem/physiol Actions: Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway).
Biochem/physiol Actions: Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death. It is extensively used to study the effect of receptor-interacting protein kinase 1 (RIPK1) on cell death and inflammation in experimental disease models. Nec‐1 protects hippocampal (HT‐22) cells from glutamate‐induced oxytosis via increasing cellular glutathione (GSH) levels, decreasing reactive oxygen species production, inhibiting the nuclear translocation of apoptosis‐inducing factor and B-cell lymphoma 2 (Bcl‐2) /adenovirus E1B 19kDa‐interacting protein 3‐related pathways.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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