Netropsin dihydrochloride

SIGMA/N9653 - from Streptomyces netropsis, ≥98% (HPLC), powder

Synonym: Congocidin; Sinanomycin

CAS Number: 18133-22-7
Empirical Formula (Hill Notation): C₁₈H₂₆N₁₀O₃ · 2HCl
Molecular Weight: 503.39
Linear Formula: C₁₈H₂₆N₁₀O₃ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N9653-5MG	5 mg	$352.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	viruses
assay	≥98% (HPLC)
biological source	Streptomyces netropsis
color	faintly yellow
form	powder
InChI	1S/C18H26N10O3.2ClH/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22;;/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24);2*1H
InChI key	SDRHUASONSRLFR-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	[H]Cl.[H]Cl.NC(CCNC(C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2C)=O)=CN1C)=O)=N
solubility	H₂O: 1 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
Disclaimer:	Protect from light.
Packaging:	5 mg in glass bottle

RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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