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Oxolinic acid

SIGMA/O0877 - quinolone antibiotic

Synonym: 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

CAS Number: 14698-29-4
Empirical Formula (Hill Notation): C13H11NO5
Molecular Weight: 261.23
EC Number: 238-750-8
MDL Number: MFCD00056775
Linear Formula: C13H11NO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-O0877-5G 5 g
 $152.00
1/EA		 Add To Favorites
45-O0877-25G 25 g
 $590.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
InChI 1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
InChI key KYGZCKSPAKDVKC-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
solubility 0.5 M NaOH: soluble 50 mg/mL
storage temp. 2-8°C
Application: Oxolinic acid is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia coli and Salmonella enterica. Oxolinic acid is added to culture medium for the isolation of Gardnerella vaginalis.
Biochem/physiol Actions: Oxolinic acid is a quinolone antibiotic. It is a DNA-gyrase (topoisomerase II) inhibitor used for studies on DNA winding and coiling and acts as a dopamine reuptake inhibitor for studies on dopaminergic neurotransmission processes.
General description: Chemical structure: quinolone
Other Notes: 5g,25g
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51282935

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