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Ozagrel hydrochloride hydrate

SIGMA/O1385 - ≥98% (HPLC), solid

Synonym: (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate; OKY-046

CAS Number: 78712-43-3
Empirical Formula (Hill Notation): C13H12N2O2 · HCl · xH2O
Molecular Weight: 264.71 (anhydrous basis)
MDL Number: MFCD00911569
Linear Formula: C13H12N2O2 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-O1385-5MG 5 mg
 $124.00
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assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C13H12N2O2.ClH.H2O/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15;;/h1-8,10H,9H2,(H,16,17);1H;1H2/b6-5+;;
InChI key OWIZTYOMGVTSDP-TXOOBNKBSA-N
Quality Level 100 
SMILES string O.Cl.OC(=O)C=Cc1ccc(Cn2ccnc2)cc1
solubility H2O: soluble
storage condition desiccated
storage temp. room temp
Application: Ozagrel hydrochloride hydrate has been used as a thromboxane synthase inhibitor:
• in high cholesterol-diet rats (HC) to test its effect on arteriolar constriction
• to pre-treat mice to test its effect on lipopolysaccharide (LPS)-induced behavioral changes
• to test its effect on arteriolar vasoconstriction in hyperglycemic mice
Biochem/physiol Actions: Ozagrel is a selective thromboxane A2 synthase (TXA2) inhibitor.
Biochem/physiol Actions: Ozagrel is useful in treating lacunar and thrombotic stroke. It blocks vasoconstriction and platelet aggregation. Ozagrel aids in improving the prostacyclin (PGI2)/ thromboxane A2 (TXA2) in the acute phase of cerebral ischemia. It improves endothelial dysfunction in L-methionine-induced hyperhomocysteinemia (HHcy)-induced vascular cognitive impairment and dementia (VCID).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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