Ochratoxin A

SIGMA/O1877 - from Petromyces albertensis, ≥98% (HPLC)

Synonym: N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine

CAS Number: 303-47-9
Empirical Formula (Hill Notation): C₂₀H₁₈ClNO₆
Molecular Weight: 403.81
MDL Number: MFCD00078079
Linear Formula: C₂₀H₁₈ClNO₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-O1877-1MG	1 mg	$140.00 1/EA	Add To Favorites
45-O1877-5MG	5 mg	$525.00 1/EA	Add To Favorites
45-O1877-25MG	25 mg	$2130.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: O1877-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	Petromyces albertensis
form	powder
impurities	Benzene, free
InChI	1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
InChI key	RWQKHEORZBHNRI-BMIGLBTASA-N
mode of action	enzyme \| inhibits
	protein synthesis \| interferes
Quality Level	300
SMILES string	C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
solubility	ethanol: soluble
storage temp.	2-8°C

Application:	Ochratoxin A has been used as a mycotoxin: • to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells • to test its cytotoxic effects in bovine mammary epithelial cells • as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells
Biochem/physiol Actions:	Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.
Biochem/physiol Actions:	Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.
Packaging:	1, 5, 25 mg in glass bottle
Preparation Note:	This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 - H351
Precautionary statements	P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
Hazard Codes	T+
Risk Statements	28-40
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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