Orotic acid
SIGMA/O2750 - ≥98% (titration), anhydrous
Synonym: 2,6-
CAS Number: 65-86-1
Empirical Formula (Hill Notation): C5H4N2O4
Molecular Weight: 156.10
EC Number: 200-619-8
MDL Number: MFCD00006027
Linear Formula: C5H4N2O4
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: O2750-10G
This image depicts SKU: O2750-10G
| assay | ≥98% (titration) |
| grade | anhydrous |
| InChI | 1S/C5H4N2O4/c8-3-1-2(4(9) |
| InChI key | PXQPEWDEAKTCGB-UHFFFAOYSA |
| mp | ≥300 °C |
| Quality Level | 200  |
| SMILES string | OC(=O)C1=CC(=O)NC(=O)N1 |
| Application: | Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis. |
| Packaging: | 10 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (titration) |
| mp | ≥300 °C |
| UNSPSC | 41106305 |