Oxamflatin

SIGMA/O3139 - ≥98% (HPLC), solid

Synonym: (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid

CAS Number: 151720-43-3
Empirical Formula (Hill Notation): C₁₇H₁₄N₂O₄S
Molecular Weight: 342.37
MDL Number: MFCD00949087
Linear Formula: C₁₇H₁₄N₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-O3139-1MG	1 mg	$205.00 1/EA		Add To Favorites
45-O3139-5MG	5 mg	$723.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	solid
InChI	1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
InChI key	QRPSQQUYPMFERG-LFYBBSHMSA-N
Quality Level	100
SMILES string	ONC(=O)C=CC#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
solubility	DMSO: soluble 13 mg/mL
storage temp.	2-8°C

Application:	Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor: • to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells • to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation • to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system • to study its stand-alone effect on cytarabine-sensitive and resistant cells.
Biochem/physiol Actions:	Histone deacetylase inhibitor; anti-cancer agent.
Biochem/physiol Actions:	Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352203

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