Oxytocin

SIGMA/O4375 - lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

Synonym: α-Hypophamine; Oxytocic hormone

CAS Number: 50-56-6
Empirical Formula (Hill Notation): C₄₃H₆₆N₁₂O₁₂S₂
Molecular Weight: 1007.19
MDL Number: MFCD00076731
Linear Formula: C₄₃H₆₆N₁₂O₁₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-O4375-250IU	250 I.U.	$27.40 1/EA	Add To Favorites
45-O4375-1000IU	1000 I.U.	$83.60 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: O4375-1000IU

Properties
Descriptions
Safety Info.
Basic Data

biological source	synthetic
form	lyophilized powder
InChI	1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
InChI key	XNOPRXBHLZRZKH-DSZYJQQASA-N
Quality Level	200
shipped in	ambient
SMILES string	[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
solubility	water: 10 mg/mL, clear, colorless
specific activity	~15 IU/mg solid (Prepared from synthetic oxytocin)
sterility	non-sterile
storage temp.	2-8°C
UniProt accession no.	P01178
	P30559
	P70536

Amino Acid Sequence:	Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Application:	Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.
Biochem/physiol Actions:	Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Biochem/physiol Actions:	Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.
General description:	Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.
Packaging:	1000 I.U. in glass bottle
Packaging:	250 I.U. in poly bottle
Physical form:	Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

activity	specific activity: ~15 IU/mg solid (Prepared from synthetic oxytocin)
Storage Temp.	2-8°C
UNSPSC	51111800

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