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Oxytetracycline dihydrate

SIGMA/O4636 - Assay (anhydrous basis) 95.0%-102.0%

Synonym: 5-Hydroxytetracycline dihydrate; Oxytetracycline; Oxytetracycline Anhydrous

CAS Number: 6153-64-6
Empirical Formula (Hill Notation): C22H24N2O9 · 2H2O
Molecular Weight: 496.46
EC Number: 201-212-8
MDL Number: MFCD00151234
Linear Formula: C22H24N2O9 · 2H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-O4636-10G 10 g
 $84.70
1/EA		 Add To Favorites
45-O4636-50G 50 g
 $340.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
InChI 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
InChI key IBZHEBHGZFICKS-IFLJXUKPSA-N
mode of action protein synthesis | interferes
Quality Level 200 
SMILES string O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
Analysis Note: solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions
Application: Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.
Biochem/physiol Actions: Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Biochem/physiol Actions: Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
General description: Chemical structure: tetracycline
Other Notes: 10g,50g
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
UNSPSC 51284038

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