Osteocalcin fragment 1-49 Human
SIGMA/O5761 - ≥94% (HPLC), solid
CAS Number: 136461-80-8
Empirical Formula (Hill Notation): C269H381N67O82S2
Molecular Weight: 5929.43
MDL Number: MFCD03457847
Linear Formula: C269H381N67O82S2
Product Type: Chemical
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| assay | ≥94% (HPLC) |
| form | solid |
| Quality Level | 200  |
| storage temp. | −20°C |
| UniProt accession no. | P02818  |
| Amino Acid Sequence: | Tyr-Leu-Tyr-Gln-Trp-Leu-G |
| Application: | Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12. |
| Biochem/physiol Actions: | Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue. |
| General description: | Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22. |
| General description: | Calcium-binding protein found in dentin and possibly other mineralized tissues. |
| Packaging: | 1 mg in glass bottle |
| Packaging: | 500 μg in glass bottle |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥94% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |