Oxytetracycline hydrochloride

SIGMA/O5875

Synonym: 5-Hydroxytetracycline hydrochloride

CAS Number: 2058-46-0
Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₉ · HCl
Molecular Weight: 496.89
EC Number: 218-161-2
MDL Number: MFCD00135815
Linear Formula: C₂₂H₂₄N₂O₉ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-O5875-10G	10 g	$77.10 1/EA	Add To Favorites
45-O5875-50G	50 g	$309.00 1/EA	Add To Favorites
45-O5875-100G	100 g	$479.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
color	yellow
form	powder or crystals
impurities	≤3.5% total of impurities (related substances (HPLC))
InChI	1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1
InChI key	UBDNTYUBJLXUNN-IFLJXUKPSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
solubility	soluble

Application:	Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.
Biochem/physiol Actions:	Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Biochem/physiol Actions:	Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
General description:	Chemical structure: tetracycline
General description:	Freely soluble in water, sparingly soluble in Ethanol (96%). Solution in water becomes turbid on standing owing to the precipitation of chromatograms.
Other Notes:	10g,50g,100g
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Light sensitive.Air sensitive.

Symbol	GHS08,GHS09
Signal word	Warning
Hazard statements	H361d - H411
Precautionary statements	P201 - P202 - P273 - P280 - P308 + P313 - P391
Hazard Codes	Xn
Risk Statements	63
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51284039

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