[β-Mercapto-β,β-cyclopentamethylenepropionyl¹, O-Me-Tyr², Orn⁸]-Oxytocin

SIGMA/O6887 - ≥93% (HPLC), solid

CAS Number: 77327-45-8
Empirical Formula (Hill Notation): C₄₈H₇₄N₁₂O₁₂S₂
Molecular Weight: 1075.30
MDL Number: MFCD00135712
Linear Formula: C₄₈H₇₄N₁₂O₁₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-O6887-1MG	1 mg	$418.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥93% (HPLC)
form	solid
InChI	1S/C48H74N12O12S2/c1-4-27(2)40-46(70)56-31(16-17-36(50)61)42(66)57-33(23-37(51)62)43(67)58-34(47(71)60-21-9-11-35(60)45(69)55-30(10-8-20-49)41(65)53-25-38(52)63)26-73-74-48(18-6-5-7-19-48)24-39(64)54-32(44(68)59-40)22-28-12-14-29(72-3)15-13-28/h12-15,27,30-35,40H,4-11,16-26,49H2,1-3H3,(H2,50,61)(H2,51,62)(H2,52,63)(H,53,65)(H,54,64)(H,55,69)(H,56,70)(H,57,66)(H,58,67)(H,59,68)/t27-,30-,31-,32-,33-,34-,35-,40-/m0/s1
InChI key	ZWVZXPFUQHTUKV-SZQHDTAUSA-N
Quality Level	200
SMILES string	CC[C@H](C)C1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O
storage temp.	−20°C

Amino Acid Sequence:	β-Mercapto-β,β-Cyclopentamethylenepropionyl-MeTyr-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 [Disulfide Bridge: 1-6]
Application:	[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin has been used as an oxytocin receptor antagonist: • to study the influence of blockading the oxytocin receptors in the anterior cingulate cortex on helping behavior • to determine the receptors that mediate vasopressin-stimulated anion secretion across cultured porcine vas deferens epithelial cell monolayers • to study the influence of oxytocin receptors inhibition on intravenous and in situ oxytocin effects on the urinary bladder and cardiovascular activities in sham rats
Biochem/physiol Actions:	Potent oxytocin antagonist.
Biochem/physiol Actions:	[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-also acts as an arginine vasopressin receptor 1A (AVPR1A) antagonist.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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