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Org 24598 lithium salt

SIGMA/O7639 - ≥98% (HPLC), solid

Synonym: R-(−)-N-Methyl-N-[3-[(4-trifluoromethyl)phenoxy]-3-phenyl-propyl]glycine lithium salt

CAS Number: 722456-08-8
Empirical Formula (Hill Notation): C19H19F3LiNO3
Molecular Weight: 373.30
MDL Number: MFCD08705419
Linear Formula: C19H19F3LiNO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-O7639-25MG 25 mg
 $0.00
1/EA
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assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C19H20F3NO3.Li/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22;/h2-10,17H,11-13H2,1H3,(H,24,25);/q;+1/p-1/t17-;/m1./s1
InChI key VMQXVSNARQMSDL-UNTBIKODSA-M
Quality Level 100 
SMILES string [Li+].CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2)CC([O-])=O
solubility H2O: >2 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1).
Biochem/physiol Actions: Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.
Features and Benefits: This compound is featured on the Glycine Transporters  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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