Anti-OMP antibody produced in rabbit
SIGMA/O7889 - ~2 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Olfactory Marker Protein
MDL Number: MFCD09265364
Product Type: Chemical
Immunoblotting Rat brain olfactory bulb (cytosolic S1 fraction) was separated on SDS-PAGE and blotted with Anti-OMP (Cat. No. O7889). The antibody was developed with Goat Anti-Rabbit IgG, Peroxidase conjugate (Cat. No. A0545) and chemiluminescent substrate. Lanes 1: Antibody dilution 1:2,000 2: Antibody dilution 1:2,000 + Inhibition with OMP immunizing peptide (rat 119-137) (20 μg/mL)
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~2 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~19 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction). |
| UniProt accession no. | P08523  |
| Application: | Anti-OMP antibody produced in rabbit has been used in immunohistochemistry. |
| Application: | Anti-OMP antibody produced in rabbit has been used in: • immunoblotting • double immunofluorescence • staining |
| Biochem/physiol Actions: | Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated. |
| Immunogen: | synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH. |
| Physical form: | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |