Oltipraz

SIGMA/O9389 - ≥98% (HPLC), powder

Synonym: 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione; BRN 0978110; CCRIS 4048; NSC 347901; RP 35972

CAS Number: 64224-21-1
Empirical Formula (Hill Notation): C₈H₆N₂S₃
Molecular Weight: 226.34
EC Number: 264-736-6
MDL Number: MFCD00868499
Linear Formula: C₈H₆N₂S₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-O9389-5MG	5 mg	$119.00 1/EA	Add To Favorites
45-O9389-25MG	25 mg	$478.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	red
form	powder
InChI	1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI key	CKNAQFVBEHDJQV-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC1=C(SSC1=S)c2cnccn2
solubility	DMSO: >20 mg/mL
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	Oltipraz is an activator of Nrf2.
Biochem/physiol Actions:	Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.
General description:	Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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