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Oxaliplatin

SIGMA/O9512 - powder

Synonym: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum

CAS Number: 61825-94-3
Empirical Formula (Hill Notation): C8H14N2O4Pt
Molecular Weight: 397.29
MDL Number: MFCD00866327
Linear Formula: C8H14N2O4Pt
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-O9512-5MG 5 mg
 $141.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: O9512-5MG

 

form powder
InChI 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChI key ZROHGHOFXNOHSO-BNTLRKBRSA-L
originator Sanofi Aventis
Quality Level 100 
SMILES string O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N
storage temp. 2-8°C
Application: Oxaliplatin has been used:
• as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay
• for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay
• to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells
Biochem/physiol Actions: Oxaliplatin a platinum analogue, causes DNA damage and cell death by binding to DNA and forming inter and intrastrand crosslinks preventing replication and transcription. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin is an approved drug for treating colorectal cancer. It is an active ingredient in FOLFOX (Folinic acid:5-FU:oxaliplatin in the ratio 1:10:1 of micromolar concentrations respectively). Oxaliplatin causes both acute and chronic neurotoxicity in patients in a dose dependent manner and is reversible either by reducing or stopping the drug.
Features and Benefits: This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox  and Apoptosis  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5 mg in glass insert
Storage Temp. 2-8°C
UNSPSC 12352200

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