Pomalidomide

SIGMA/P0018 - ≥98% (HPLC)

Synonym: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide; 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; Actimid; CC-4047; IMiD 3

CAS Number: 19171-19-8
Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₄
Molecular Weight: 273.24
MDL Number: MFCD12756407
Linear Formula: C₁₃H₁₁N₃O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0018-5MG	5 mg	$162.00 1/EA	Add To Favorites
45-P0018-25MG	25 mg	$673.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key	UVSMNLNDYGZFPF-UHFFFAOYSA-N
ligand	pomalidomide
Quality Level	100
reaction suitability	reagent type: ligand
SMILES string	Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
solubility	DMSO: ≥14 mg/mL
storage temp.	2-8°C

Application:	Pomalidomide has been used: • to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides • for apoptosis studies and intracellular calcium analysis • as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells
Biochem/physiol Actions:	Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.
Biochem/physiol Actions:	Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).
Features and Benefits:	This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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